Download e-book for kindle: Activation-Induced Deaminase: On the Targeting Mechanism of by Andrew Franklin

By Andrew Franklin

During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure known as affinity maturation. a bunch produces antibodies with successively larger affinities with repeated publicity to an analogous antigen, that's the primary in which so much vaccines work.
Affinity maturation depends on hypermutation, an iterative technique of mutation at antibody-encoding genes, via confident choice of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant leap forward got here in 2000 with the invention that activation-induced deaminase (AID) is actually required for hypermutation. This was once in 2002 by means of proof that reduction without delay edits the DNA that encodes an antibody in an activated B mobile. a lot has considering been learnt concerning the biochemistry and rules of reduction, however the mechanism during which it really is recruited particularly to antibody-encoding genes continues to be enigmatic. knowing this recruitment is clinically major simply because off-target reduction job at oncogenes can result in chromosomal translocations and tumorigenesis.
This e-book summarizes the learn on relief within the context of its critical function within the affinity maturation of B cells.

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Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin

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