By Pedro Merino
Compiles present validated and confirmed techniques to synthesize novel nucleoside analogues
Featuring contributions from major man made chemists from all over the world, this e-book brings jointly and describes verified and confirmed ways for the chemical synthesis of universal households of nucleoside analogues. Readers will discover ways to create new nucleoside analogues with wanted healing houses by utilizing a number of the way to chemically alter common nucleosides, including:
- Changes to the heterocyclic base
- Modification of substituents on the sugar ring
- Replacement of the furanose ring by way of a unique carbo- or heterocyclic ring
- Introduction of conformational restrictions
- Synthesis of enantiomers
- Preparation of hydrolitically strong C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers the entire significant sessions of nucleosides, together with pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers that have proven nice promise as beginning issues for the synthesis of nucleoside analogues. The booklet additionally comprises experimental techniques for key reactions on the topic of the synthesis of nucleoside analogues, supplying a useful device for the education of a few varied compounds.
Throughout the publication, chemical schemes and figures support readers larger comprehend the chemical constructions of nucleoside analogues and the tools used to synthesize them. huge references function a gateway to the growing to be physique of unique learn experiences and studies within the field.
Synthetically converted nucleosides have confirmed their price as healing medications, specifically as antiviral and antitumor brokers. although, a lot of those nucleoside analogues have bad unintended effects. With Chemical Synthesis of Nucleoside Analogues as their consultant, researchers have a brand new instrument for synthesizing a brand new iteration of nucleoside analogues that may be used as healing medicinal drugs with fewer undesirable aspect effects.
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Chemical Synthesis of Nucleoside Analogues by Pedro Merino